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Band 3 Protein Function and Oxidative Stress in Erythrocytes from Systemic Sclerosis Patients with Interstitial Lung Disease

Received: 16 May 2017     Accepted: 28 June 2017     Published: 27 July 2017
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Abstract

A link between reactive oxygen species (ROS) and Systemic Sclerosis (SSc) development has been already described, along with an oxidative stress-induced reduction of anion exchange capability through Band 3 protein. On this basis, blood from SSc patients has been collected to measure the rate constant for SO4= uptake, which is an index for anion exchange capability through Band 3 protein. This parameter was significantly reduced in SSc patients, with or without Interstitial Lung Disease, a complication of SSc. As a reduced Band 3 protein function was observed in SSc patients with either low or high levels of malonildialdehyde (MDA), the end product of lipoperoxidation, anion exchange through erythrocytes membrane may be not univocally related to oxidative stress and, what is more, can be considered as a sensitive tool to monitor SSc development.

Published in European Journal of Clinical and Biomedical Sciences (Volume 3, Issue 4)
DOI 10.11648/j.ejcbs.20170304.12
Page(s) 80-84
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Band 3 Protein, Erythrocytes, Interstitial Lung Disease, Oxidative Stress, Systemic Sclerosis

References
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Cite This Article
  • APA Style

    Rossana Morabito, Alessia Remigante, Gianluca Bagnato, William Neal Roberts, Davide Sciortino, et al. (2017). Band 3 Protein Function and Oxidative Stress in Erythrocytes from Systemic Sclerosis Patients with Interstitial Lung Disease. European Journal of Clinical and Biomedical Sciences, 3(4), 80-84. https://doi.org/10.11648/j.ejcbs.20170304.12

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    ACS Style

    Rossana Morabito; Alessia Remigante; Gianluca Bagnato; William Neal Roberts; Davide Sciortino, et al. Band 3 Protein Function and Oxidative Stress in Erythrocytes from Systemic Sclerosis Patients with Interstitial Lung Disease. Eur. J. Clin. Biomed. Sci. 2017, 3(4), 80-84. doi: 10.11648/j.ejcbs.20170304.12

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    AMA Style

    Rossana Morabito, Alessia Remigante, Gianluca Bagnato, William Neal Roberts, Davide Sciortino, et al. Band 3 Protein Function and Oxidative Stress in Erythrocytes from Systemic Sclerosis Patients with Interstitial Lung Disease. Eur J Clin Biomed Sci. 2017;3(4):80-84. doi: 10.11648/j.ejcbs.20170304.12

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  • @article{10.11648/j.ejcbs.20170304.12,
      author = {Rossana Morabito and Alessia Remigante and Gianluca Bagnato and William Neal Roberts and Davide Sciortino and Tommaso D’Angelo and Filippo Iannelli and Dario Iannelli and Francesca Cordova and Mariateresa Cirillo and Giuseppina La Spada and Angela Marino},
      title = {Band 3 Protein Function and Oxidative Stress in Erythrocytes from Systemic Sclerosis Patients with Interstitial Lung Disease},
      journal = {European Journal of Clinical and Biomedical Sciences},
      volume = {3},
      number = {4},
      pages = {80-84},
      doi = {10.11648/j.ejcbs.20170304.12},
      url = {https://doi.org/10.11648/j.ejcbs.20170304.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20170304.12},
      abstract = {A link between reactive oxygen species (ROS) and Systemic Sclerosis (SSc) development has been already described, along with an oxidative stress-induced reduction of anion exchange capability through Band 3 protein. On this basis, blood from SSc patients has been collected to measure the rate constant for SO4= uptake, which is an index for anion exchange capability through Band 3 protein. This parameter was significantly reduced in SSc patients, with or without Interstitial Lung Disease, a complication of SSc. As a reduced Band 3 protein function was observed in SSc patients with either low or high levels of malonildialdehyde (MDA), the end product of lipoperoxidation, anion exchange through erythrocytes membrane may be not univocally related to oxidative stress and, what is more, can be considered as a sensitive tool to monitor SSc development.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Band 3 Protein Function and Oxidative Stress in Erythrocytes from Systemic Sclerosis Patients with Interstitial Lung Disease
    AU  - Rossana Morabito
    AU  - Alessia Remigante
    AU  - Gianluca Bagnato
    AU  - William Neal Roberts
    AU  - Davide Sciortino
    AU  - Tommaso D’Angelo
    AU  - Filippo Iannelli
    AU  - Dario Iannelli
    AU  - Francesca Cordova
    AU  - Mariateresa Cirillo
    AU  - Giuseppina La Spada
    AU  - Angela Marino
    Y1  - 2017/07/27
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ejcbs.20170304.12
    DO  - 10.11648/j.ejcbs.20170304.12
    T2  - European Journal of Clinical and Biomedical Sciences
    JF  - European Journal of Clinical and Biomedical Sciences
    JO  - European Journal of Clinical and Biomedical Sciences
    SP  - 80
    EP  - 84
    PB  - Science Publishing Group
    SN  - 2575-5005
    UR  - https://doi.org/10.11648/j.ejcbs.20170304.12
    AB  - A link between reactive oxygen species (ROS) and Systemic Sclerosis (SSc) development has been already described, along with an oxidative stress-induced reduction of anion exchange capability through Band 3 protein. On this basis, blood from SSc patients has been collected to measure the rate constant for SO4= uptake, which is an index for anion exchange capability through Band 3 protein. This parameter was significantly reduced in SSc patients, with or without Interstitial Lung Disease, a complication of SSc. As a reduced Band 3 protein function was observed in SSc patients with either low or high levels of malonildialdehyde (MDA), the end product of lipoperoxidation, anion exchange through erythrocytes membrane may be not univocally related to oxidative stress and, what is more, can be considered as a sensitive tool to monitor SSc development.
    VL  - 3
    IS  - 4
    ER  - 

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Author Information
  • Department Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy

  • Department Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy

  • Department Clinical and Experimental Medicine, University of Messina, Messina, Italy

  • Department Medicine, University of Louisville, Kentucky, US

  • Department Clinical and Experimental Medicine, University of Messina, Messina, Italy

  • Department Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy

  • Department Clinical and Experimental Medicine, University of Messina, Messina, Italy

  • Department Clinical and Experimental Medicine, University of Messina, Messina, Italy

  • Department Clinical and Experimental Medicine, University of Messina, Messina, Italy

  • Department Clinical and Experimental Medicine, University of Messina, Messina, Italy

  • Department Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy

  • Department Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy

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